Selected article for: "different affinity and MHC class"
Author: Kaliamurthi, Satyavani; Selvaraj, Gurudeeban; Kaushik, Aman Chandra; Gu, Ke-Ren; Wei, Dong-Qing
Title: Designing of CD8(+) and CD8(+)-overlapped CD4(+) epitope vaccine by targeting late and early proteins of human papillomavirus
  • Document date: 2018_10_2
    • ID: j0runrkf_29
    Snippet: cD8 + cTl epitopes In total, 80 CTL epitopes were predicted from the early proteins E1 (19) , E2 (17), E4 (01), E6 (05), and E7 (14), and late proteins L1 (07) and L2 (17) of HPV45 based on MHC class I supertype by NetCTL 1.2 (threshold value >0.75). Among the 80 epitopes, only 50 CTL epitopes showed a higher binding affinity (IC 50 <200 nm) for MHC class I alleles as found using NetMHC ANN 3.4. Table 1 depicts the proteasome score, TAP score, MH.....
    Document: cD8 + cTl epitopes In total, 80 CTL epitopes were predicted from the early proteins E1 (19) , E2 (17), E4 (01), E6 (05), and E7 (14), and late proteins L1 (07) and L2 (17) of HPV45 based on MHC class I supertype by NetCTL 1.2 (threshold value >0.75). Among the 80 epitopes, only 50 CTL epitopes showed a higher binding affinity (IC 50 <200 nm) for MHC class I alleles as found using NetMHC ANN 3.4. Table 1 depicts the proteasome score, TAP score, MHC score, processing score, total score, and binding affinity of predicted epitopes for different alleles as determined using NetMHC ANN 3.4. According to the results, 17 out of 19 epitopes of E1 protein, such as ATDTGSDMV 40

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