Viral Respiratory Tract Infection During the First Postoperative Year Is a Risk Factor for Chronic Rejection After Lung Transplantation

Magnusson, Jesper; Westin, Johan; Andersson, Lars-Magnus; Lindh, Magnus; Brittain-Long, Robin; Nordén, Rickard; Riise, Gerdt C.

Comparisons of the group levels for numerical variables were performed using the Mann-Whitney U test, and for categorical variables, the Fisher exact test (2-sided). Kaplan-Meier analysis and the log-rank test were used to calculate and compare the CLAD-free survival and time until graft loss for time-independent covariates. Acute rejection, bacterial infection, fungal infection, VRTI, CMV viremia, and REED were handled as time-dependent covariates for appropriate assignment of hazard. A univariate Cox proportional hazards model was used for examining the association between covariates and CLAD-free survival and graft loss respectively. Covariates with a P value less than 0.2 in the univariate analysis were included in the multivariate model. The SPSS software package version 22.0.0 (IBM, Armonk, NY) was used for all statistical analyses, and a P value less than 0.05 was considered significant.