Selected article for: "II MHC Class epitope and MHC Class II epitope"
Author: Zhao, Jingxian; Zhao, Jincun; Fett, Craig; Trandem, Kathryn; Fleming, Erica; Perlman, Stanley
Title: IFN-?– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis
  • Document date: 2011_8_1
    • ID: k751ryv4_8
    Snippet: We previously showed that virus-specific effector CD4 and CD8 T cells were detected in the infected brain at 6-7 d after infection (Haring et al., 2001) . MHC class II/peptide tetramers are available for detecting epitope M133-specific CD4 T cells, and using these tetramers, we also detected M133-specific T reg cells in the brain and spinal cord at 7 d after infection (Fig. 1 , C and E). Furthermore, M133-specific T reg cells were present in the .....
    Document: We previously showed that virus-specific effector CD4 and CD8 T cells were detected in the infected brain at 6-7 d after infection (Haring et al., 2001) . MHC class II/peptide tetramers are available for detecting epitope M133-specific CD4 T cells, and using these tetramers, we also detected M133-specific T reg cells in the brain and spinal cord at 7 d after infection (Fig. 1 , C and E). Furthermore, M133-specific T reg cells were present in the infected CNS until at least 49 d after infection. M133-specific T reg cells were not routinely detected above background in draining cervical LNs (CLNs) or spleen (unpublished data). Staining with M133 tetramer was specific because no positive cells were detected in mice infected with an rJ2.2 variant in which the epitope was mutated, abrogating recognition (rJ.2.2.M Y135Q ; Fig. 1 D; Anghelina et al., 2006) .

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