Author: Mauthe, Mario; Langereis, Martijn; Jung, Jennifer; Zhou, Xingdong; Jones, Alex; Omta, Wienand; Tooze, Sharon A.; Stork, Björn; Paludan, Søren Riis; Ahola, Tero; Egan, Dave; Behrends, Christian; Mokry, Michal; de Haan, Cornelis; van Kuppeveld, Frank; Reggiori, Fulvio
Title: An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication Document date: 2016_8_29
ID: iuqa0yrw_36
Snippet: The proof-of-principle study on FIP200 and ATG13 validated our ATG-specific siRNA screening approach as a platform to identify unconventional roles of ATG proteins. The screen thus strongly supports the emerging concept that ATG proteins do not participate exclusively in autophagy. It also calls for caution in interpreting results on the contribution of autophagy to a specific process that relies solely on the depletion of a single ATG protein......
Document: The proof-of-principle study on FIP200 and ATG13 validated our ATG-specific siRNA screening approach as a platform to identify unconventional roles of ATG proteins. The screen thus strongly supports the emerging concept that ATG proteins do not participate exclusively in autophagy. It also calls for caution in interpreting results on the contribution of autophagy to a specific process that relies solely on the depletion of a single ATG protein.
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