Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages

Weishan Huang; Sabrina Solouki; Chavez Carter; Song-Guo Zheng; Avery August

Nb infection did not lead to significant up-regulation of LAG3/CD49b co-expression on IL-10 -CD4 + 220 T cells (Fig. 2E&F) . However, the percentage of the LAG3 + CD49b + population of IL-10 + CD4 + T 221 cells is significantly higher than their IL-10counterparts ( Fig. 2F) . Moreover, the levels of LAG3 222 and CD49b expression are similar between the Foxp3 + and Foxp3counterparts of IL-10 + CD4 + T 223 cells (Fig. 2G) . Therefore, IL-10-producing CD4 + T cells, regardless of Foxp3 expression, have a 224 high capacity of co-expressing LAG3 and CD49b. Together with the data shown in Fig. 1 , these 225 data suggest that co-expression of LAG3 and CD49b is a generic feature of IL-10-producing T 226 cells, including Foxp3 -Tr1 cells, Foxp3 + Treg cells and CD8 + T cells. 227