Author: Casanova, Victor; Sousa, Filipa H; Stevens, Craig; Barlow, Peter G
Title: Antiviral therapeutic approaches for human rhinovirus infections Document date: 2018_6_12
ID: kl7holv4_13
Snippet: Studies have shown that deficiency in LL-37 in humans leads to an increased susceptibility to infection [73] , and mice deficient in the murine cathelicidin (mCRAMP) also display an increased susceptibility to both bacterial and viral infections of the airway tract, skin, urinary tract and gut [74, 75, 76] . On the contrary, exogenous delivery of LL-37 in murine models offered enhanced clearance and reduced mortality in lethal influenza infection.....
Document: Studies have shown that deficiency in LL-37 in humans leads to an increased susceptibility to infection [73] , and mice deficient in the murine cathelicidin (mCRAMP) also display an increased susceptibility to both bacterial and viral infections of the airway tract, skin, urinary tract and gut [74, 75, 76] . On the contrary, exogenous delivery of LL-37 in murine models offered enhanced clearance and reduced mortality in lethal influenza infection [77] .
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