Author: Mordecai, Gideon J; Wilfert, Lena; Martin, Stephen J; Jones, Ian M; Schroeder, Declan C
Title: Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies Document date: 2015_11_17
ID: k2n6ropo_37
Snippet: As well as being of significance to globally important honey bee health, the ability to study highly heterogeneous virus genomes is of wider importance. Cross-species virus transmission and emergence of new epidemic diseases such as severe acute respiratory syndrome, Ebola and influenza are major threats to public health (Parrish et al., 2008) . Exploring the extent of viral diversity in RNA quasispecies, of which DWV may be a suitable model, may.....
Document: As well as being of significance to globally important honey bee health, the ability to study highly heterogeneous virus genomes is of wider importance. Cross-species virus transmission and emergence of new epidemic diseases such as severe acute respiratory syndrome, Ebola and influenza are major threats to public health (Parrish et al., 2008) . Exploring the extent of viral diversity in RNA quasispecies, of which DWV may be a suitable model, may offer insight into the mechanisms by which viruses are able to transmit between different hosts as well as how viruses are able to develop resistance to antiviral therapies (Domingo et al., 2012) . Further study of the DWV quasispecies may help to explain how DWV is able to exist as multiple variants in many hosts, and may elucidate mechanisms by which it establishes a persistent infection among several hosts but only proves pathogenic in some.
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