Author: Mammas, Ioannis N.; Greenough, Anne; Theodoridou, Maria; Kramvis, Anna; Rusan, Maria; Melidou, Angeliki; Korovessi, Paraskevi; Papaioannou, Georgia; Papatheodoropoulou, Alexia; Koutsaftiki, Chryssie; Liston, Maria; Sourvinos, George; Spandidos, Demetrios A.
Title: Paediatric Virology and its interaction between basic science and clinical practice (Review) Document date: 2018_1_4
ID: ix314s4n_5
Snippet: The importance of diet during the first years of life. A number of different infections occur during the early period of life (6) . Several of these infections are viral, e.g., herpes-group viruses, polyomaviruses and Torque teno viruses, and these result in long-time persistence and latency within human specific cell types (6) . The fate of the latent genomes seems to vary substantially. They may remain dormant for the whole lifetime without any.....
Document: The importance of diet during the first years of life. A number of different infections occur during the early period of life (6) . Several of these infections are viral, e.g., herpes-group viruses, polyomaviruses and Torque teno viruses, and these result in long-time persistence and latency within human specific cell types (6) . The fate of the latent genomes seems to vary substantially. They may remain dormant for the whole lifetime without any recognisable side effect. During prolonged latency, their genomes may become defective and can eventually be degraded. In particular, herpes-group viruses may become re-activated, leading locally to viral production and cell lysis. The interaction of the latent genomes with mutagenic chemical, physical or other biological factors may dysregulate the control of latency or persistence and may thus result in local exacerbations, mainly as the result of immunoreactivity (6) .
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