Selected article for: "critically impact and decrease mortality"
Author: McCreary, Erin K; Pogue, Jason M
Title: Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options
  • Document date: 2020_3_23
    • ID: j0i9ozsz_35
    Snippet: The clinical data for use of corticosteroids in SARS-CoV-1 infections are mixed. Multiple analyses show no impact on outcomes [47] , one report demonstrates decreased mortality in critically ill patients [48] , and others have documented worse outcomes for patients receiving steroids, including increased time to viral clearance [49] or an increase in the composite endpoint of ICU admission or death [50] . In MERS-CoV, receipt of corticosteroids h.....
    Document: The clinical data for use of corticosteroids in SARS-CoV-1 infections are mixed. Multiple analyses show no impact on outcomes [47] , one report demonstrates decreased mortality in critically ill patients [48] , and others have documented worse outcomes for patients receiving steroids, including increased time to viral clearance [49] or an increase in the composite endpoint of ICU admission or death [50] . In MERS-CoV, receipt of corticosteroids has been associated with a delayed time until viral clearance in a large cohort (n = 309) of infected patients [51] . However, this same data set showed a nonsignificant reduction in 90-day mortality in patients receiving corticosteroids (adjusted odds ratio = 0.75; 95% CI, 0.52-1.07) after accounting for differences between the groups in a regression model accounting for time-varying exposures. Finally, recent evidence in SARS-CoV-2 suggested a decrease in mortality in patients with ARDS with the receipt of corticosteroids (23 of 50 [46%] vs 21 of 34 [62%] without; hazard ratio, 0.38; 95% CI, 0.20-0.72) [52] .

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