Author: Jain, K.K.
Title: Synthetic Biology and Personalized Medicine Document date: 2012_8_16
ID: jejgkcql_14
Snippet: The ability to control expression in target areas within a genome is important for synthetic biologists who are developing chemical-producing organisms for commercial applications. In Transcription Activator-Like (TAL) Effector Technology, two hypervariable amino acid residues in each repeat recognize 1 bp in the target DNA [10] . Recognition sequences of TAL effectors are predictable. The TAL code is similar to a navigation system for the genome.....
Document: The ability to control expression in target areas within a genome is important for synthetic biologists who are developing chemical-producing organisms for commercial applications. In Transcription Activator-Like (TAL) Effector Technology, two hypervariable amino acid residues in each repeat recognize 1 bp in the target DNA [10] . Recognition sequences of TAL effectors are predictable. The TAL code is similar to a navigation system for the genome, allowing pinpoint delivery of functional control elements to any specified sequence. The modular protein architecture has enabled the construction of artificial effectors with new specificities.
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