Atti del 52° Congresso Nazionale: Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI)

These encouraging results lead us to apply this model in women with a history of breast cancer. In collaboration with the OU of Oncology, "Santa Maria della Misericordia" hospital of Urbino, we are starting a project entitled "Movimento e Salute oltre la Cura" (Movement and Health beyond Care), MoviS (CESU approved n. 21, 10 th July 2019). The general objective of the project MoviS is to improve the quality of life (QoL) of breast cancer survivors (BCS). This proposal stems from the need to respond to the requests of numerous women with a history of breast cancer, which perceive their lifestyle as unhealthy but lack the necessary tools to move towards a correct diet and regular physical activity. The strongest evidence regarding lifestyle changes and cancer risk comes from the link with obesity; however, there is significant evidence that physical inactivity per se increases the risk of cancer and relapse regardless of body weight. Throughout the planned trial period, the food plan will be prescribed by the nutritionists of the IRCCS National Cancer Institute (INT) Milan following the guidelines indicated in the DianaWeb project 6 , based on the recommendations of the WCRF 2018 and on the Mediterranean diet. The exercise protocols will be designed according to the most recent internationally recognized guidelines for the prescription of physical activity with health and preventive purposes in cancer patients 7 , which are perfectly in line with the Italian guidelines on physical activity for these patients, recently published by the Ministry of Health. During the intermediate follow-up, various parameters will be evaluated, such as the QoL, the reduction of the 'fatigue', the reduction of body weight and the modifications induced on the relevant metabolic and clinical parameters in order to verify the beneficial effects of the prescribed exercise Within this project, we planned to collect serum samples before and after exercise sessions and use them in cell growth assays, in order to verify and quantify the efficacy of exercise in the inhibition of cell proliferation and tumorigenicity. Overall, the positive effects of the exercise-oncology on cancer progression control recently gained attention. Despite the anticancer component released in response to an acute exercise have not been fully understood, there is growing evidence that acute systemic changes can control cancer cell viability and proliferation. To move forward in the translational development of the use of precise exercise for cancer treatment, there is a need of additional studies on preclinical testing, preliminary safety, and efficacy trials, and definitive clinical exercise trials with survival endpoints 2 , with the aim of a controlled and personalized administration of acute exercise bouts by exercise experts.