Selected article for: "SARS cov and vitro exist"
Author: McCreary, Erin K; Pogue, Jason M
Title: Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options
  • Document date: 2020_3_23
    • ID: j0i9ozsz_21
    Snippet: This compelling mortality difference in SARS-CoV-1 and continued investigation in MERS-CoV led to inclusion of LPV/r in the Chinese SARS-CoV-2 guidelines at a dose of 400 mg/100 mg (2 capsules/tablets) by mouth twice a day for no more than 10 days even though to our knowledge, no in vitro data for LPV/r in SARS-CoV-2 exist [29] . In pediatric patients weighing 15-40 kg, the recommended dose in the United States is 10 mg/kg suspension by mouth twi.....
    Document: This compelling mortality difference in SARS-CoV-1 and continued investigation in MERS-CoV led to inclusion of LPV/r in the Chinese SARS-CoV-2 guidelines at a dose of 400 mg/100 mg (2 capsules/tablets) by mouth twice a day for no more than 10 days even though to our knowledge, no in vitro data for LPV/r in SARS-CoV-2 exist [29] . In pediatric patients weighing 15-40 kg, the recommended dose in the United States is 10 mg/kg suspension by mouth twice daily. There are 10 ongoing registered clinical trials in China, Korea, Thailand, and Hong Kong evaluating LPV/r as monotherapy or in combination with other antivirals (eg, ribavirin, interferon beta-1b) or traditional Chinese medicine for treatment of COVID-19.

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