Author: Zhao, Jingxian; Zhao, Jincun; Fett, Craig; Trandem, Kathryn; Fleming, Erica; Perlman, Stanley
Title: IFN-?– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis Document date: 2011_8_1
ID: k751ryv4_16
Snippet: To further investigate whether these T reg cells were derived from natural T reg cells, we measured expression of the helios, a transcription factor. Helios has been reported to be expressed by natural but not peripherally converted T reg cells (Thornton et al., 2010) . Some M133 + S358-specific IFN-î§ + T reg cells in the infected brain expressed high level of helios, consistent with an origin in natural T reg cell populations (Fig. S4) . Howev.....
Document: To further investigate whether these T reg cells were derived from natural T reg cells, we measured expression of the helios, a transcription factor. Helios has been reported to be expressed by natural but not peripherally converted T reg cells (Thornton et al., 2010) . Some M133 + S358-specific IFN-î§ + T reg cells in the infected brain expressed high level of helios, consistent with an origin in natural T reg cell populations (Fig. S4) . However, many of the IFN-î§ + cells were helios intermediate, making it uncertain as to whether all of these cells were thymically derived.
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