Author: Noh, Heeju; Shoemaker, Jason E; Gunawan, Rudiyanto
Title: Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection Document date: 2018_4_6
ID: j80hnhpb_18
Snippet: where a positive (negative) b kjq describes the activation (repression) of the kth gene by a protein q through its interaction with the TF protein j. The variables n TF and n P denote the numbers of TFs and their protein partners, respectively. The multiplication of two variables r j and r q implies that the regulation of gene k by protein q requires the TF protein j (a non-zero r j ). The model in Equation (2) can be simplified into:.....
Document: where a positive (negative) b kjq describes the activation (repression) of the kth gene by a protein q through its interaction with the TF protein j. The variables n TF and n P denote the numbers of TFs and their protein partners, respectively. The multiplication of two variables r j and r q implies that the regulation of gene k by protein q requires the TF protein j (a non-zero r j ). The model in Equation (2) can be simplified into:
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