Author: Zhu, Zhen-Hong; Song, Wen-Qi; Zhang, Chang-Qing; Yin, Ji-Min
Title: Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head Document date: 2016_9_13
ID: kjvy2c2k_2
Snippet: Previous studies have described the use of mesenchymal stem cells (MSCs) to promote local bone repair and healing (5, 6) . MSCs are pluripotent and can differentiate into several lineages of cells, which have shown potency in the treatment of numerous ischemic diseases, such as myocardial infarction (7, 8) , nerve injury (9) and bone defect (10) . Prior studies have found that the implantation of MSCs into the necrotic area of the femoral head wa.....
Document: Previous studies have described the use of mesenchymal stem cells (MSCs) to promote local bone repair and healing (5, 6) . MSCs are pluripotent and can differentiate into several lineages of cells, which have shown potency in the treatment of numerous ischemic diseases, such as myocardial infarction (7, 8) , nerve injury (9) and bone defect (10) . Prior studies have found that the implantation of MSCs into the necrotic area of the femoral head was able to improve local bone regeneration (11, 12) . MSCs are able to differentiate into osteoblasts to promote local bone healing directly (13, 14) . Furthermore, MSCs are able to secrete growth factors such as vascular endothelial growth factor (VEGF), angiopoietin 1, stromal cell-derived factor 1 and basic fibroblast growth factor, which have angiogenic potency and can promote local revascularization, thereby improving bone healing indirectly (15, 16) .
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