Author: Gao, Shuibo; Li, Enyao; Gao, Haixia
Title: Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway Document date: 2019_8_21
ID: jwrv3e6j_5
Snippet: Herein, mouse hippocampal neuronal HT22 cells were exposed to morphine stimulation. The OX1R, c-fos, p/t-ERK and p/t-PKC expressions in HT22 cells, along with the HT22 cell autophagy were tested. What's more, the MEG3 expression, as well as the influence of MEG3 up-regulation on morphinecaused HT22 cell autophagy were probed. We believe that the outcomes of our research will offer experimental basis for comprehending the influence of lncRNAs on m.....
Document: Herein, mouse hippocampal neuronal HT22 cells were exposed to morphine stimulation. The OX1R, c-fos, p/t-ERK and p/t-PKC expressions in HT22 cells, along with the HT22 cell autophagy were tested. What's more, the MEG3 expression, as well as the influence of MEG3 up-regulation on morphinecaused HT22 cell autophagy were probed. We believe that the outcomes of our research will offer experimental basis for comprehending the influence of lncRNAs on morphine-mediated drug addiction. Morphine solution was received from Sigma-Aldrich (M-005, St. Louis, MO, USA). HT22 cells were exposed to 10 mM morphine for 24 h in our experiments. SCH772984 was received from MedChem Express (HY-50846, NJ, USA). 50 mM SCH772984 was added into the culture medium of HT22 cells to inhibit the ERK pathway.
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