Author: Noh, Heeju; Shoemaker, Jason E; Gunawan, Rudiyanto
Title: Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection Document date: 2018_4_6
ID: j80hnhpb_29
Snippet: wherer lk denotes the average residual of gene k among the drug treatment samples, σ k denotes the sample standard deviation of the residuals in all samples besides the drug treatment, and n l denotes the number of samples from the drug treatment. A positive (negative) z-score indicates that the expression of gene k in the particular sample was higher (lower) than expected based on the expression of its regulators. The greater the magnitude of t.....
Document: wherer lk denotes the average residual of gene k among the drug treatment samples, σ k denotes the sample standard deviation of the residuals in all samples besides the drug treatment, and n l denotes the number of samples from the drug treatment. A positive (negative) z-score indicates that the expression of gene k in the particular sample was higher (lower) than expected based on the expression of its regulators. The greater the magnitude of the z-score, the more significant is the gene dysregulation.
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