Author: Chan, Renee W. Y.; Poon, Leo L. M.
Title: The Emergence of Human Coronavirus EMC: How Scared Should We Be? Document date: 2013_4_9
ID: kna8kca6_4
Snippet: Since the first discovery of HCoV-EMC as the etiological agent of this novel severe respiratory disease (1, 2), researchers have used various strategies to understand virus entry and its replication capability in mammalian cell lines (3, 4) . In the absence of autopsy reports of patients who died from HCoV-EMC, our understanding of virus tropism and pathogenesis in humans is inadequate. Kindler et al. (5) describe the efficient infection and repl.....
Document: Since the first discovery of HCoV-EMC as the etiological agent of this novel severe respiratory disease (1, 2), researchers have used various strategies to understand virus entry and its replication capability in mammalian cell lines (3, 4) . In the absence of autopsy reports of patients who died from HCoV-EMC, our understanding of virus tropism and pathogenesis in humans is inadequate. Kindler et al. (5) describe the efficient infection and replication of HCoV-EMC in differentiated human primary airway epithelial (HAE) cell cultures in vitro. This model was used to culture other human coronaviruses such as HCoV-OC43 and HCoV-NL63 (6). This well-characterized primary culture system exhibits high physiological relevance, reflecting the anatomy of the human conducting airway (7) , and allows better understanding of the cellular tropism of this newly emerged virus.
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