Author: Gao, Shuibo; Li, Enyao; Gao, Haixia
Title: Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway Document date: 2019_8_21
ID: jwrv3e6j_27
Snippet: Some lncRNAs have been found to engage in neuroplasticity via modulating protein dynamics in the synapse (Sartor et al. 2012; Bohnsack et al. 2019) . Given that addiction can be regarded as a process of synaptic plasticity (Luscher and Malenka 2011) , it is worthy believing that identifying the roles of lncRNAs in this process will provide novel insights for addiction research. In the current research, we further confirmed the influences of morph.....
Document: Some lncRNAs have been found to engage in neuroplasticity via modulating protein dynamics in the synapse (Sartor et al. 2012; Bohnsack et al. 2019) . Given that addiction can be regarded as a process of synaptic plasticity (Luscher and Malenka 2011) , it is worthy believing that identifying the roles of lncRNAs in this process will provide novel insights for addiction research. In the current research, we further confirmed the influences of morphine on OX1R, c-fos, p/t-ERK and p/t-PKC expressions in mouse hippocampal neuronal HT22 cells, as well as HT22 cell autophagy. We proposed that morphine-stimulated HT22 cells could be utilized as an in vitro cell model of drug addiction.
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