Selected article for: "blood testis barrier and male infertility"
Author: Zhang, Yongli; Zhang, Hangjie; Ma, Wenqiang; Liu, Kefang; Zhao, Min; Zhao, Yingze; Lu, Xuancheng; Zhang, Fuping; Li, Xiangdong; Gao, George F.; Liu, William J.
Title: Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1(-/-) Mice
  • Document date: 2018_10_17
    • ID: km6fnf5u_1
    Snippet: The ZIKV is a mosquito-borne flavivirus that was first isolated in 1947 in Uganda from a febrile rhesus macaque. Recently, the ZIKV has become a public health emergency, due to its rapid dissemination in the Americas and its unexpected link to microcephaly and Guillain-Barré syndrome 1, 2, 3 . From epidemiological data, the ZIKV has been suspected to be the cause of the Guillain-Barré syndrome in around 1 per 4,000 infected adults 4 . Moreover,.....
    Document: The ZIKV is a mosquito-borne flavivirus that was first isolated in 1947 in Uganda from a febrile rhesus macaque. Recently, the ZIKV has become a public health emergency, due to its rapid dissemination in the Americas and its unexpected link to microcephaly and Guillain-Barré syndrome 1, 2, 3 . From epidemiological data, the ZIKV has been suspected to be the cause of the Guillain-Barré syndrome in around 1 per 4,000 infected adults 4 . Moreover, a correlation between the ZIKV and testes infection/damage in the mouse model has been demonstrated, suggesting that the ZIKV infection, under certain circumstances, can bypass the blood-testis barrier and eventually lead to male infertility 5 . These findings highlight the importance of completely understanding the induction of protective or pathologic immune responses during a ZIKV infection.

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