Selected article for: "current gate and gate current"
Author: Brandon Alexander Holt; Gabriel A. Kwong
Title: Bacterial defiance as a form of prodrug failure
  • Document date: 2019_2_21
    • ID: 9le4s67m_17
    Snippet: Our model revealed that bacterial defiance arises during prodrug monotherapy when 5 environmental parameters, as represented by a dimensionless constant, crosses a critical transition BAH value. To combat bacterial defiance, we therefore sought to design a multi-prodrug approach to eliminate defiant bacteria that would otherwise resist treatment to a single prodrug (Fig. 4A) . To do this, we recognized that the bacterial switch from susceptibilit.....
    Document: Our model revealed that bacterial defiance arises during prodrug monotherapy when 5 environmental parameters, as represented by a dimensionless constant, crosses a critical transition BAH value. To combat bacterial defiance, we therefore sought to design a multi-prodrug approach to eliminate defiant bacteria that would otherwise resist treatment to a single prodrug (Fig. 4A) . To do this, we recognized that the bacterial switch from susceptibility to defiance could be considered as behaving analogously to electronic transistorstransistors allow input current 10 (Iin) to pass (Iout) when the gate voltage (G) crosses a threshold, whereas with AMP prodrugs, input bacteria (Bin) survive treatment (Bout) when the BAH (gate) crosses a critical value (Fig. 4B) .

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