Author: Mauthe, Mario; Langereis, Martijn; Jung, Jennifer; Zhou, Xingdong; Jones, Alex; Omta, Wienand; Tooze, Sharon A.; Stork, Björn; Paludan, Søren Riis; Ahola, Tero; Egan, Dave; Behrends, Christian; Mokry, Michal; de Haan, Cornelis; van Kuppeveld, Frank; Reggiori, Fulvio
Title: An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication Document date: 2016_8_29
ID: iuqa0yrw_35
Snippet: proteins, and although we did not observe major differences in viral replication structures in ATG13 knockdown cells, these proteins could still participate in the optimal establishment of picornaviral replication structures. Because ATG13 has been implicated in selective forms of autophagy in mammalian cells and plants (Joo et al., 2011; Li et al., 2014) , there is also the possibility that ATG13 and eventually FIP200 function in one of these pa.....
Document: proteins, and although we did not observe major differences in viral replication structures in ATG13 knockdown cells, these proteins could still participate in the optimal establishment of picornaviral replication structures. Because ATG13 has been implicated in selective forms of autophagy in mammalian cells and plants (Joo et al., 2011; Li et al., 2014) , there is also the possibility that ATG13 and eventually FIP200 function in one of these pathways to prevent picornavirus replication. The exact mechanism by which ATG13 and FIP200 affects picornavirus genomic RNA replication remains to be established. Therefore, the RNA-sequencing and MS datasets that we generated in this study are valuable tools for future studies aimed at unraveling the precise unconventional cellular function of ATG13 and FIP200.
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