Author: Zhu, Zhen-Hong; Song, Wen-Qi; Zhang, Chang-Qing; Yin, Ji-Min
Title: Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head Document date: 2016_9_13
ID: kjvy2c2k_3
Snippet: Hypoxia inducible factor-1α (HIF-1α) is a key mediator of the adaptive cell response to hypoxia, which controls the expression of numerous genes and modulates cell proliferation, differentiation and pluripotency (17) . Previous experiments have suggested that HIF-1α could enhance the osteogenic differentiation of MSCs and the expression of angiogenic factors, thus promoting their bone healing capacity (18) . In a prior study, we implanted HIF-.....
Document: Hypoxia inducible factor-1α (HIF-1α) is a key mediator of the adaptive cell response to hypoxia, which controls the expression of numerous genes and modulates cell proliferation, differentiation and pluripotency (17) . Previous experiments have suggested that HIF-1α could enhance the osteogenic differentiation of MSCs and the expression of angiogenic factors, thus promoting their bone healing capacity (18) . In a prior study, we implanted HIF-1α transgenic MSCs into the necrotic area of the femoral head, and found that this treatment resulted in improved osteogenic and angiogenic capacity in vitro and in vivo, leading to better results for early-stage ONFH (19) . However, the risks of lentivirus vectors, such as tumorigenesis (20) , should be seriously considered before clinical application.
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