Author: Pruitt, Hawley C.; Devine, Daniel J.; Samant, Rajeev S.
Title: Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination Document date: 2016_3_11
ID: k3vjqumq_10
Snippet: domain of ATM. 12 Ionizing radiation intensifies the interaction between NMI and Tip60 and leads to enhanced expression of both proteins. 13 NMI was shown to associate with Tip60 in cytoplasmic speckles. Acetyltransferase activity of Tip60 is necessary to stabilize NMI levels, but the interaction of Tip60 and NMI is not dependent on acyltransferase activity, nor is NMI found to be acetylated by Tip60. 13 These studies implicate NMI in this proces.....
Document: domain of ATM. 12 Ionizing radiation intensifies the interaction between NMI and Tip60 and leads to enhanced expression of both proteins. 13 NMI was shown to associate with Tip60 in cytoplasmic speckles. Acetyltransferase activity of Tip60 is necessary to stabilize NMI levels, but the interaction of Tip60 and NMI is not dependent on acyltransferase activity, nor is NMI found to be acetylated by Tip60. 13 These studies implicate NMI in this process by association, which again supports the proposition that NMI has a myriad of functions in cancer-related mechanisms, each dependent on its protein-protein interaction.
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