Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate

Basso, Maria Alexandra; Marques, Cátia; Santos, Marcos; Duarte, Ana; Pissarra, Hugo; Carreira, L Miguel; Gomes, Lídia; Valério-Bolas, Ana; Tavares, Luís; Santos-Gomes, Gabriela; Pereira da Fonseca, Isabel

Dermatological findings in FeL usually include erythema, alopecia, papules, nodules, ulcers or crusts, with the head being the most affected region, but other body parts may also be affected. 17, 25, 26 In the present clinical case, as the ulcers in the hindlimbs were severely contaminated at first examination, it was not possible to determine whether the fever was a systemic sign of FeL or a consequence of secondary bacterial infection. Concerning the available therapeutics for FeL, this cat was first treated with allopurinol, which was insufficient despite its use being common in the treatment of canine leishmaniosis. Even though the use of allopurinol is offlabel in both dogs and cats, there is a more extensive clinical experience of efficacy and safety in dogs. Under the scope of 'cascade' a combined therapeutic not yet approved for cats was suggested to the owner.