Clinical findings and treatment of disseminated ‘Mycobacterium avium subspecies hominissuis’ infection in a domestic cat

KANEGI, Ryoji; YASUGI, Mayo; NABETANI, Tomoyo; TANAKA, Toshiyuki; WADA, Yusuke; HIRAI, Kotaro; SUGIURA, Kikuya; HATOYA, Shingo

ry 24 hr, rifampicin 10 mg/kg every 24 hr, and enrofloxacin 5 mg/kg every 24 hr) on day 66 of illness. However, atonic seizures occurred in increasing frequency from day 93 of illness. The chest X-ray and ultrasound imaging revealed the improvement of lung disease and jejunum lymph node swelling, which indicated the therapeutic response of MAH infection. We administered pyridoxal phosphate (1 mg/kg every 24 hr) and clarithromycin (10 mg/kg every 12 hr) instead of isoniazid. Atonic seizures disappeared within a week. On day 107 of illness, lung disease was in remission and the jejunum lymph node had begun to shrink. On day 246 of illness, CT scan revealed that the peribronchial consolidation and the multiple nodules of the liver had disappeared ( Fig. 3C and 3D ). Furthermore, bronchus and liver FNA specimens were culture-negative in Mycobacteria Growth Indicator Tube systems. We stopped antibiotic administration on day 429 of illness, and there were no clinical signs, evidence of lung disease in chest X-Ray, or obvious lymph node swelling in ultrasound images on day 771 of illness.