Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_36
Snippet: A similar inhibitory activity was recently described for two IFNc-inducible GTPases, termed guanylate-binding proteins 2 and 5 (GBP2 and GBP5). Initially, GBP5 was described in a screening for novel restriction factors of HIV and shown to interfere with the maturation of the retroviral Env protein. 94, 95 Follow-up experiments revealed that this antiviral activity is shared by its paralogue GBP2 and that both proteins reduce the proteolytically a.....
Document: A similar inhibitory activity was recently described for two IFNc-inducible GTPases, termed guanylate-binding proteins 2 and 5 (GBP2 and GBP5). Initially, GBP5 was described in a screening for novel restriction factors of HIV and shown to interfere with the maturation of the retroviral Env protein. 94, 95 Follow-up experiments revealed that this antiviral activity is shared by its paralogue GBP2 and that both proteins reduce the proteolytically active amount of furin. As a result, cleavage of the Env precursor gp160 into mature gp120 and gp41 is reduced and newly formed virions are only poorly infectious (Figure 4b ).
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