Selected article for: "host immune response innate and immune response innate"
Author: Bautista-Hernández, Luis Antonio; Gómez-Olivares, José Luis; Buentello-Volante, Beatriz; Bautista-de Lucio, Victor Manuel
Title: Fibroblasts: The Unknown Sentinels Eliciting Immune Responses Against Microorganisms
  • Document date: 2017_8_19
    • ID: j4lfwdbh_42
    Snippet: The innate immune response comprises different mechanisms to defend the host against pathogenic agents, for example, in the case of the physical barriers in the skin or ocular surfaces where the barriers are constituted by layers that have specialized cells with certain functions. The fi broblasts are stromal cells that play an important role in establishing a response against microorganisms. We consider that fi broblasts are stromal sentinel cel.....
    Document: The innate immune response comprises different mechanisms to defend the host against pathogenic agents, for example, in the case of the physical barriers in the skin or ocular surfaces where the barriers are constituted by layers that have specialized cells with certain functions. The fi broblasts are stromal cells that play an important role in establishing a response against microorganisms. We consider that fi broblasts are stromal sentinel cells that possess "weapons" as TLR's to recognize microbial agents. When the pathogens are recognized, the fi broblasts begin to synthesize cytokines and growth factors to expand the immune responses and fi nally secrete antimicrobial peptides as "mortal weapons" to prevent or eliminate the establishment of the invading enemies.

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