Selected article for: "bone healing and prolyl hydroxylase"
Author: Zhu, Zhen-Hong; Song, Wen-Qi; Zhang, Chang-Qing; Yin, Ji-Min
Title: Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head
  • Document date: 2016_9_13
    • ID: kjvy2c2k_4
    Snippet: Dimethyloxalylglycine (DMOG) is a cell permeable prolyl-4-hydroxylase inhibitor, which is able to stabilize expression of HIF-1α in cells at normal oxygen tension (21) . Therefore, DMOG is hypothesized to be an alternative strategy for enhancing HIF-1α expression in MSCs. In a previous study, we demonstrated that DMOG could increase HIF-1α expression in MSCs, accordingly enhancing their bone healing capacity (22) . In the present study, we inv.....
    Document: Dimethyloxalylglycine (DMOG) is a cell permeable prolyl-4-hydroxylase inhibitor, which is able to stabilize expression of HIF-1α in cells at normal oxygen tension (21) . Therefore, DMOG is hypothesized to be an alternative strategy for enhancing HIF-1α expression in MSCs. In a previous study, we demonstrated that DMOG could increase HIF-1α expression in MSCs, accordingly enhancing their bone healing capacity (22) . In the present study, we investigated whether DMOG was able to enhance the bone repair capacity of adipose-derived stem cells (ASCs) in treating early-stage ONFH.

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