Author: Kun Sun; Liuqi Gu; Li Ma; Yunfeng Duan
Title: Atlas of ACE2 gene expression in mammals reveals novel insights in transmission of SARS-Cov-2 Document date: 2020_3_31
ID: 89sg0cpk_25
Snippet: Mouse is the most widely used model species in biomedical studies, including those related to SARS-CoV-2. We extracted the expression data of murine Ace2 gene from Tabula Muris project 36 , which investigated various murine tissues using single-cell RNA-seq experiments. Murine Ace2 gene was expressed in kidney, heart, intestine, and pancreas (Figures 3 and S1 in Supplementary data), a pattern similar to human ( Figure 2A ). However, murine Ace2.....
Document: Mouse is the most widely used model species in biomedical studies, including those related to SARS-CoV-2. We extracted the expression data of murine Ace2 gene from Tabula Muris project 36 , which investigated various murine tissues using single-cell RNA-seq experiments. Murine Ace2 gene was expressed in kidney, heart, intestine, and pancreas (Figures 3 and S1 in Supplementary data), a pattern similar to human ( Figure 2A ). However, murine Ace2 gene was not expressed in any cell types in lungs, while expressed in tongue and skin ( Figure 3B ). The data also suggested that ACE2 gene expression pattern could be species-specific among mammals. In particular, lungrelated symptoms may not be expected when infecting SARS-CoV-2 to normal mice.
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