Selected article for: "dieckol inhibitory effect and inhibitory effect"
Author: Kang, Na-Jin; Koo, Dong-Hwan; Kang, Gyeoung-Jin; Han, Sang-Chul; Lee, Bang-Won; Koh, Young-Sang; Hyun, Jin-Won; Lee, Nam-Ho; Ko, Mi-Hee; Kang, Hee-Kyoung; Yoo, Eun-Sook
Title: Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-? Stimulated HaCaT Human Keratinocytes
  • Document date: 2015_5_1
    • ID: k6f3luil_22
    Snippet: STAT1 protein is a crucial and specific regulator of IFN-γinduced signals that controls the transcription of target genes, including MDC (Ivashkiv and Hu. 2004; Best et al., 2005; Kang et al., 2008; Rauch et al., 2013) . Therefore, we tested the effect of dieckol on the activation of STAT1 in IFN-γ-treated HaCaT keratinocytes and detected a high level of phosphorylated (Fig. 3A ). In addition, microscopy results showed that IFN-γ led to nuclea.....
    Document: STAT1 protein is a crucial and specific regulator of IFN-γinduced signals that controls the transcription of target genes, including MDC (Ivashkiv and Hu. 2004; Best et al., 2005; Kang et al., 2008; Rauch et al., 2013) . Therefore, we tested the effect of dieckol on the activation of STAT1 in IFN-γ-treated HaCaT keratinocytes and detected a high level of phosphorylated (Fig. 3A ). In addition, microscopy results showed that IFN-γ led to nuclear translocation of STAT1 within 1 h, and dieckol (5, 10 mM) suppressed the nuclear translocation of phosphorylated STAT1 (serine 727) (Fig. 3B) . These results suggest that the inhibitory effect of dieckol on the production of MDC occurs through inhibiting the activation and nuclear translocation of STAT1.

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