Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_34
Snippet: Viral pathogens and their hosts are in a continuous arms race. 88 Although viruses have evolved sophisticated strategies to exploit the metabolism, protein synthesis and trafficking pathways of an infected cell, the host is not defenceless. Besides innate and adaptive immune responses that directly target components of the virus, infected cells may also restrict viral spread by limiting the availability of cellular factors that are critical for v.....
Document: Viral pathogens and their hosts are in a continuous arms race. 88 Although viruses have evolved sophisticated strategies to exploit the metabolism, protein synthesis and trafficking pathways of an infected cell, the host is not defenceless. Besides innate and adaptive immune responses that directly target components of the virus, infected cells may also restrict viral spread by limiting the availability of cellular factors that are critical for viral replication, so-called 'virus dependency factors'. For example, the host protein SAMHD1 restricts replication of several viral pathogens by depleting cellular dNTP levels. 89 Furthermore, IFI16 targets the cellular transcription factor Sp1 to suppress viral gene expression. 90 Intriguingly, accumulating evidence suggests that inhibition of the virus dependency factor furin represents another efficient and broadly active mechanism of antiviral immunity.
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