Author: McCreary, Erin K; Pogue, Jason M
Title: Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options Document date: 2020_3_23
ID: j0i9ozsz_26
Snippet: Nitazoxanide has demonstrated potent in vitro activity against SARS CoV-2, with an EC 50 at 48 hours of 2.12 µM in Vero E6 cells [3] . This potent activity is consistent with EC 50 values for nitazoxanide and its active metabolite, tizoxanide, against MERS-CoV in LLC-MK2 cells in which EC 50 values of 0.92 and 0.83 µM, respectively, have been demonstrated [39] . Nitazoxanide displays broad-spectrum in vitro antiviral activity against influenza,.....
Document: Nitazoxanide has demonstrated potent in vitro activity against SARS CoV-2, with an EC 50 at 48 hours of 2.12 µM in Vero E6 cells [3] . This potent activity is consistent with EC 50 values for nitazoxanide and its active metabolite, tizoxanide, against MERS-CoV in LLC-MK2 cells in which EC 50 values of 0.92 and 0.83 µM, respectively, have been demonstrated [39] . Nitazoxanide displays broad-spectrum in vitro antiviral activity against influenza, respiratory syncytial virus, parainfluenza, rotavirus, and norovirus among others in addition to coronaviruses [39] . This broad-spectrum antiviral activity is believed to be due to the fact that the mechanism of action is based on interference with host-regulated pathways involved in viral replication rather than virus-specific pathways [39] .
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