Author: van de Hei, Susanne; McKinstry, Steven; Bardsley, George; Weatherall, Mark; Beasley, Richard; Fingleton, James
Title: Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study Document date: 2018_3_27
ID: iys2ezkd_50
Snippet: Participants had symptoms for a mean of 31 hours at presentation, at which time the mean 291 modified Jackson score was 11.7 (Table 1 ). There were 27 participants who completed the 292 modified Jackson score after ten days. Table 2 shows the mean (SD), median (IQR) and the 293 range of the modified Jackson score from baseline to day 10 for both groups. The mean change 294 in modified Jackson score from baseline was greater in the rhinothermy gro.....
Document: Participants had symptoms for a mean of 31 hours at presentation, at which time the mean 291 modified Jackson score was 11.7 (Table 1 ). There were 27 participants who completed the 292 modified Jackson score after ten days. Table 2 shows the mean (SD), median (IQR) and the 293 range of the modified Jackson score from baseline to day 10 for both groups. The mean change 294 in modified Jackson score from baseline was greater in the rhinothermy group than in the 295 control group after 24 hours, and remained significantly greater than the control group until day 296 6 ( Table 3) . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 In total 27 participants reported feeling "a lot better" within 10 days of randomisation; 17/20 310 participants from the rhinothermy group and all 10 control group participants. Two participants did 311 not fill in the modified Jackson score on the day they felt "a lot better". Therefore, an estimate of 312 the MCID used the scores of 25 participants, 16 in the rhinothermy group and nine in the control 313 group. We recognised post-hoc that the threshold "a lot better" corresponded to an estimate of 314 substantial clinical benefit rather than the MCID [31,32] and so have estimated the change which 315 represents substantial clinical benefit. The change from baseline modified Jackson score which 316 had the best sensitivity and specificity for the participants stating that they felt a lot better was 317 between 5 and 6 units on the modified Jackson Score on days 4 and 5 ( The difference in modified Jackson score between the rhinothermy group and the control group 322 was greater than the substantial clinical benefit threshold on days three, four, and five, p<0.001 323 (Table 3) . 324
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