Selected article for: "ACE inhibitor and angiotensin II type ACE inhibitor"
Author: Harlan Barker; Seppo Parkkila
Title: Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2
  • Document date: 2020_4_13
    • ID: 08vsaov7_41
    Snippet: Previous studies have suggested that both ACE inhibitor and angiotensin II receptor type I antagonist therapies increase ACE2 mRNA expression in the rat heart (58) . There has also been some evidence in humans showing increased expression of ACE2 in the heart, brain, and even in urine after treatment with angiotensin receptor blockers (57) . Since these drugs are widely used for treatment of hypertension and heart failure, it would be important t.....
    Document: Previous studies have suggested that both ACE inhibitor and angiotensin II receptor type I antagonist therapies increase ACE2 mRNA expression in the rat heart (58) . There has also been some evidence in humans showing increased expression of ACE2 in the heart, brain, and even in urine after treatment with angiotensin receptor blockers (57) . Since these drugs are widely used for treatment of hypertension and heart failure, it would be important to determine in COVID-19 patients whether these medications have any significant effects on symptoms or outcome of the disease.

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