Author: Gao, Shuibo; Li, Enyao; Gao, Haixia
Title: Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway Document date: 2019_8_21
ID: jwrv3e6j_25
Snippet: Finally, the inhibitor of ERK pathway SCH772984 was added into experiment to analyse the roles of ERK pathway in morphine-caused HT22 cell autophagy. Figure 6 showed that 50 mM SCH772984 incubation significantly declined the Beclin-1 protein level and LC3-II/LC3-I expression rate in morphine-treated HT22 cells (p ˂ 0.01), which illustrated that ERK pathway played important role in HT22 cell autophagy. In addition, by contrast with morphine þ si.....
Document: Finally, the inhibitor of ERK pathway SCH772984 was added into experiment to analyse the roles of ERK pathway in morphine-caused HT22 cell autophagy. Figure 6 showed that 50 mM SCH772984 incubation significantly declined the Beclin-1 protein level and LC3-II/LC3-I expression rate in morphine-treated HT22 cells (p ˂ 0.01), which illustrated that ERK pathway played important role in HT22 cell autophagy. In addition, by contrast with morphine þ si-MEG3 group, the Beclin-1 protein level and LC3-II/LC3-I expression rate in HT22 cells were further declined in morphine þ si-MEG3 group þ SCH772984 group (p ˂ 0.05), which illustrated that up-regulation of MEG3 took part in the influence of morphine on HT22 cell autophagy might be achieved by promoting ERK pathway activation.
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