Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

Harlan Barker; Seppo Parkkila

. CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.038752 doi: bioRxiv preprint Figure 7 . Prediction of transcription factor binding sites in the human ACE2 gene promoter regions of Ensembl transcripts ENST00000252519 and ENST00000427411 using TFBSfootprinter. A) Promoter region of the intestine specific ACE2 transcript. The results show putative binding sites for several transcription factors which have a strong correlation of expression with ACE2 in colon, kidney, and ileum. The predicted binding sites overlap regions of conservation in mammal species (Ensembl GERP), and cluster within 400 base pairs (bp) of the transcription start site. B) Promoter region of the lung specific ACE2 transcript. The predicted binding sites cluster within 200 bp of the TSS and overlap regions of conservation in mammal species, ATAC-Seq peaks (ENCODE), and TFBS metaclusters (GTRD).