Author: Mitchell Holland; Daniel Negrón; Shane Mitchell; Nate Dellinger; Mychal Ivancich; Tyler Barrus; Sterling Thomas; Katharine W. Jennings; Bruce Goodwin; Shanmuga Sozhamannan
Title: BioLaboro: A bioinformatics system for detecting molecular assay signature erosion and designing new assays in response to emerging and reemerging pathogens Document date: 2020_4_10
ID: eifrg2fe_39
Snippet: By periodically re-running BioLaboro on emerging and reemerging pathogen sequences 421 as they become available, over time the relative diversity can be monitored, and assays can be 422 updated to remain current with regards to available data. By tracking assay performance 423 measures over time, one can evaluate the efficacy of MCMs on a routine basis. These analyses 424 would ensure that the most accurate MCMs are available when an outbreak res.....
Document: By periodically re-running BioLaboro on emerging and reemerging pathogen sequences 421 as they become available, over time the relative diversity can be monitored, and assays can be 422 updated to remain current with regards to available data. By tracking assay performance 423 measures over time, one can evaluate the efficacy of MCMs on a routine basis. These analyses 424 would ensure that the most accurate MCMs are available when an outbreak response is 425 necessary. In this study we demonstrate the value of real-time genomic sequencing and MCM 426 evaluation to provide actionable information before and during a public health emergency.
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