Selected article for: "adaptive innate immunity and cell type"

Author: Liu, Wei
Title: Some latest achievements in immunology research
  • Document date: 2011_12_3
  • ID: j0b4fos6_9
    Snippet: Dendritic cells (DCs) are professional antigen-presenting cells within the immune system, crucial for the innate and adaptive immune responses to infections. Plasmacytoid dendritic cells (pDCs), an important type of dendritic cells, represent a unique and crucial immune cell population capable of producing type I interferons (IFNs) in response to viral infection [22] . Tang et al. [23] working in the laboratory from which pDCs were indentified 10.....
    Document: Dendritic cells (DCs) are professional antigen-presenting cells within the immune system, crucial for the innate and adaptive immune responses to infections. Plasmacytoid dendritic cells (pDCs), an important type of dendritic cells, represent a unique and crucial immune cell population capable of producing type I interferons (IFNs) in response to viral infection [22] . Tang et al. [23] working in the laboratory from which pDCs were indentified 10 year ago, dedicated another chapter by reviewing the remarkable progress within the past decade in understanding pDC biology, with focusing on the molecular mechanisms in antiviral immunity and autoimmunity [23] . Cellular properties, including the morphology, surface phenotype, development, location and migration of human pDCs are recounted in the first part, while physiological and pathophysiological functions of pDCs in both antiviral immunity and autoimmunity are narrated in the following part. Increasingly available data suggest that pDCs sense nucleic acids through TLR7 and TLR9, two members of the Toll-like receptor family [24, 25] , and link innate and adaptive immunity by promoting the antiviral functions of myeloid dendritic cells (mDCs), natural killer (NK) cells, T cells and B cells [26] . Considerable emerging evidences argue that the chronically activated pDCs and the IFN- that they produce in response to self DNA/RNA are contributing factors in the pathogenesis of some autoimmune diseases, such as systemic lupus erythematosus (SLE) and psoriasis. Despite greatly enhanced understanding of pDC biology achieved recently, a number of fascinating questions requiring further investigation are crucial to develop safe and effective immunotherapy for viral infectious diseases and autoimmune diseases.

    Search related documents:
    Co phrase search for related documents
    • adaptive innate infection immune response and immune system: 1, 2, 3, 4, 5, 6, 7, 8
    • adaptive innate infection immune response and infection immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
    • adaptive innate infection immune response and infectious disease: 1
    • adaptive innate infection immune response and past decade: 1
    • adaptive innate infection immune response and type interferon: 1
    • adaptive innate infection immune response and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • adaptive innate infection immune response and viral infectious disease: 1
    • adaptive link innate immunity and antiviral immunity: 1
    • adaptive link innate immunity and autoimmune disease: 1
    • adaptive link innate immunity and IFNs type interferon: 1
    • adaptive link innate immunity and immune response: 1
    • adaptive link innate immunity and immune system: 1, 2
    • adaptive link innate immunity and important type: 1
    • adaptive link innate immunity and natural killer: 1, 2
    • adaptive link innate immunity and past decade: 1
    • adaptive link innate immunity and type interferon: 1, 2
    • adaptive link innate immunity and viral infection: 1, 2, 3
    • antigen present and autoimmune disease: 1, 2
    • antigen present and cell population: 1