Selected article for: "animal model and early stage"
Author: Zhu, Zhen-Hong; Song, Wen-Qi; Zhang, Chang-Qing; Yin, Ji-Min
Title: Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head
  • Document date: 2016_9_13
    • ID: kjvy2c2k_33
    Snippet: This study used a rabbit model with steroid-induced early-stage ONFH. An animal model of ONFH is important for evaluation of the effects of various methods of treating ONFH. In the present model, osteonecrosis was induced by a combination of LPS and MPS to mimic the pathological mechanism of steroid-induced ONFH. It has been reported that this inductive protocol has a high incidence of ONFH, and resulted in nearly no death, and suggested that num.....
    Document: This study used a rabbit model with steroid-induced early-stage ONFH. An animal model of ONFH is important for evaluation of the effects of various methods of treating ONFH. In the present model, osteonecrosis was induced by a combination of LPS and MPS to mimic the pathological mechanism of steroid-induced ONFH. It has been reported that this inductive protocol has a high incidence of ONFH, and resulted in nearly no death, and suggested that numerous histopathological and pathogenetic features of steroid-induced ONFH in rabbits are similar to those observed in human early-stage ONFH (25) . Therefore, the steroid-induced rabbit ONFH model may be effective for testing the efficacy of the method developed for treatment of steroid-associated ONFH for clinical application and confirmation of their long-term effects in prevention of subchondral bone collapse of the hips.

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