Author: Braun, Elisabeth; Sauter, Daniel
Title: Furin-mediated protein processing in infectious diseases and cancer Document date: 2019_8_5
ID: k3m72uxw_42
Snippet: Besides stability, the subcellular localisation of furin inhibitors is a key determinant of their efficacy in vivo. Notably, optimal localisation of the inhibitor strongly depends on the processing event targeted for therapeutic intervention. To inhibit activation of anthrax toxin, for example, the inhibitor does not need to enter the cells, as . PAR1 as well as GBP2 and GBP5 reduces HIV particle infectivity by inhibiting furin-mediated Env proce.....
Document: Besides stability, the subcellular localisation of furin inhibitors is a key determinant of their efficacy in vivo. Notably, optimal localisation of the inhibitor strongly depends on the processing event targeted for therapeutic intervention. To inhibit activation of anthrax toxin, for example, the inhibitor does not need to enter the cells, as . PAR1 as well as GBP2 and GBP5 reduces HIV particle infectivity by inhibiting furin-mediated Env processing. Human immunodeficiency virus (HIV) particles containing functional mature envelope (Env) glycoproteins fuse with the plasma membrane of the target cell to release the capsid core into the host cell cytoplasm. Upon reverse transcription and integration of the retroviral genome, viral gene expression is initiated.
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