Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study

van de Hei, Susanne; McKinstry, Steven; Bardsley, George; Weatherall, Mark; Beasley, Richard; Fingleton, James

Participants who used Vitamin C returned the bottle for medicines reconciliation. 220 221 All participants were requested to complete a symptom diary every day for 10 days. The diary 222 comprised a daily modified Jackson score questionnaire and a box to tick when they first felt "a 223 lot better" compared to study entry. The mean change in modified Jackson score when 224 participants felt "a lot better" was used to estimate the MCID. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 Participants had symptoms for a mean of 31 hours at presentation, at which time the mean 300 modified Jackson score was 11.7 (Table 1 ). There were 27 participants who completed the 301 modified Jackson score after ten days. Table 2 shows the mean (SD), median (IQR) and the 302 range of the modified Jackson score from baseline to day 10 for both groups. The mean change 303 in modified Jackson score from baseline was greater in the rhinothermy group than in the 304 control group after 24 hours, and remained greater than the control group until day 6 (Tables 3 305 and S1). Figure 3 shows a plot of the change from baseline of the modified Jackson score. 306 307