Author: Bautista-Hernández, Luis Antonio; Gómez-Olivares, José Luis; Buentello-Volante, Beatriz; Bautista-de Lucio, Victor Manuel
Title: Fibroblasts: The Unknown Sentinels Eliciting Immune Responses Against Microorganisms Document date: 2017_8_19
ID: j4lfwdbh_15
Snippet: Fibroblasts can recognize viral molecules. TLR3 is implicated in the recognition of viral molecules such as double-stranded RNA (dsRNA) [9] . This behavior was observed in myofi broblasts stimulated with poly I:C that mimic a viral infection [23] . Epstein Barr virus is a γ-herpes virus involved in systemic sclerosis (SSc) or scleroderma. This virus induces TLR3 expression in fi broblasts [24] . These data indicate the ability of fi broblasts to.....
Document: Fibroblasts can recognize viral molecules. TLR3 is implicated in the recognition of viral molecules such as double-stranded RNA (dsRNA) [9] . This behavior was observed in myofi broblasts stimulated with poly I:C that mimic a viral infection [23] . Epstein Barr virus is a γ-herpes virus involved in systemic sclerosis (SSc) or scleroderma. This virus induces TLR3 expression in fi broblasts [24] . These data indicate the ability of fi broblasts to recognize PAMPs through the TLRs of different microorganisms and to carry out a synthesis of antimicrobial peptides, proinfl ammatory cytokines, and chemokines, as well as growth factors, to contain the pathogens (Fig. 1) .
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