Selected article for: "downstream structure and frameshift efficiency"
Author: Mouzakis, Kathryn D.; Lang, Andrew L.; Vander Meulen, Kirk A.; Easterday, Preston D.; Butcher, Samuel E.
Title: HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome
  • Document date: 2012_12_15
    • ID: ix8du1er_5
    Snippet: For frameshift sites with a downstream pseudoknot structure, mechanical stability has been proposed to be a determinant of frameshift efficiency (46) (47) (48) . It has been hypothesized that mechanical tension lowers the energy barrier for frameshifting (5) , where the amount of tension sensed by the ribosome is proportional to the mechanical stability of the translocation barrier (46, 47, (49) (50) (51) . However, a recent study found no correl.....
    Document: For frameshift sites with a downstream pseudoknot structure, mechanical stability has been proposed to be a determinant of frameshift efficiency (46) (47) (48) . It has been hypothesized that mechanical tension lowers the energy barrier for frameshifting (5) , where the amount of tension sensed by the ribosome is proportional to the mechanical stability of the translocation barrier (46, 47, (49) (50) (51) . However, a recent study found no correlation between pseudoknot mechanical stability and frameshift efficiency, but instead observed a correlation between frameshifting and the ability to form alternative structures (52) .

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