Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_26
Snippet: CMAH homologs were detected in all of the studied echinoderms, hemichordates, and cephalochordates; however, no CMAH orthologs (active or inactive) were detected in urochordates. These results indicate that CMAH was present in the ancestor of deuterostomes, and it was lost in an ancestor of urochordates. Figure 1 summarizes the distribution of CMAH homologs across nonvertebrate deuterostomes, and supplementary table S2, Supplementary Material onl.....
Document: CMAH homologs were detected in all of the studied echinoderms, hemichordates, and cephalochordates; however, no CMAH orthologs (active or inactive) were detected in urochordates. These results indicate that CMAH was present in the ancestor of deuterostomes, and it was lost in an ancestor of urochordates. Figure 1 summarizes the distribution of CMAH homologs across nonvertebrate deuterostomes, and supplementary table S2, Supplementary Material online, contains a detailed description of all found genes. Supplementary data set S1, Supplementary Material online, is a multiple sequence alignment of representative nonvertebrate deuterostome sequences.
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