Author: Kim, Eun; Erdos, Geza; Huang, Shaohua; Kenniston, Thomas; Falo, Louis D.; Gambotto, Andrea
Title: Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation Document date: 2016_10_3
ID: jzcyxjxt_21
Snippet: As expected, all pups of PBS-immunized dams showed neurological signs including loss of balance, paresis, and hindlimb paralysis, with 4.62 ± 1.30 of neurological score. However, five out of six pups of MNA-ZIKV-rEfl-immunized dams exhibited neurological illness (no significant difference from the percentage of PBS group; P = 0.2482), although the neurological severity score was significantly lower than that of pups from PBS-immunized mice (P b .....
Document: As expected, all pups of PBS-immunized dams showed neurological signs including loss of balance, paresis, and hindlimb paralysis, with 4.62 ± 1.30 of neurological score. However, five out of six pups of MNA-ZIKV-rEfl-immunized dams exhibited neurological illness (no significant difference from the percentage of PBS group; P = 0.2482), although the neurological severity score was significantly lower than that of pups from PBS-immunized mice (P b 0.05). In contrast, the pups from Ad5.ZIKV-Efl-immunized mice showed mild symptoms at one time point or no signs of neurological illness (Table 1) .
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