Author: Jain, K.K.
Title: Synthetic Biology and Personalized Medicine Document date: 2012_8_16
ID: jejgkcql_50
Snippet: Controlling gene expression is the key to stem cell differentiation for applications such as tissue regeneration and cancer therapy. Stem cells can be developed into specialized cells, e.g. cardiomyocytes, by insertion of specific sequences. A simple, non-integrating strategy has been described for induced pluripotent stem cells (iPSCs) based on administration of synthetic mRNA that function as mRNA transcripts for the four key genes [27] . The t.....
Document: Controlling gene expression is the key to stem cell differentiation for applications such as tissue regeneration and cancer therapy. Stem cells can be developed into specialized cells, e.g. cardiomyocytes, by insertion of specific sequences. A simple, non-integrating strategy has been described for induced pluripotent stem cells (iPSCs) based on administration of synthetic mRNA that function as mRNA transcripts for the four key genes [27] . The transcripts are translated into proteins that induce pluripotency without the integration of extra genes into the genomes, which can also be used to efficiently direct the differentiation of RNA-iPSCs into terminally differentiated myogenic cells. This strategy for somatic cell reprogramming and directing cell fate can be applied for basic research and regenerative medicine.
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