Author: Weishan Huang; Sabrina Solouki; Chavez Carter; Song-Guo Zheng; Avery August
Title: Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages Document date: 2018_6_30
ID: ivyp5cgz_41
Snippet: Despite the shared feature of co-expression of LAG3 and CD49b by IL-10-producing 346 we observed an increased proportion of IL-10 + LAG3 + CD49b + T cells that are CD8 + , which is the 355 predominant population in the Flu model (Fig. 3F) . This discrepancy in the composition of IL-10-356 producing LAG3 + CD49b + T cells may be due to the difference of the microenvironment in which in IL-10-producing CD8 + T cells either [65] , suggesting that Ah.....
Document: Despite the shared feature of co-expression of LAG3 and CD49b by IL-10-producing 346 we observed an increased proportion of IL-10 + LAG3 + CD49b + T cells that are CD8 + , which is the 355 predominant population in the Flu model (Fig. 3F) . This discrepancy in the composition of IL-10-356 producing LAG3 + CD49b + T cells may be due to the difference of the microenvironment in which in IL-10-producing CD8 + T cells either [65] , suggesting that AhR signaling has multifaceted 373 function in regulating the level of IL-10 expression in different T cell lineages. A more 374 comprehensive understanding of the T cell-intrinsic molecular features that are shared or distinct 375 among the IL-10-producing CD8 + , Foxp3 -CD4 + and Foxp3 + CD4 + T cells awaits further 376
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