Author: Peri, Sateesh; Kulkarni, Asmita; Feyertag, Felix; Berninsone, Patricia M; Alvarez-Ponce, David
Title: Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc Document date: 2017_12_30
ID: k596omcy_25
Snippet: We next focused our analyses on the 322 deuterostome genomes available from the NCBI Genome database, including those for 8 echinoderms, 2 hemichordates, 3 cephalochordates, 5 urochordates (tunicates), and 304 vertebrates (table 1). These represent almost completely sequenced genomes. The CMAH mRNA sequence for another two echinoderm species were obtained from the NCBI nr database: Asterias rubens (ID: AJ308602.1) (Martensen et al. 2001) and Hemi.....
Document: We next focused our analyses on the 322 deuterostome genomes available from the NCBI Genome database, including those for 8 echinoderms, 2 hemichordates, 3 cephalochordates, 5 urochordates (tunicates), and 304 vertebrates (table 1). These represent almost completely sequenced genomes. The CMAH mRNA sequence for another two echinoderm species were obtained from the NCBI nr database: Asterias rubens (ID: AJ308602.1) (Martensen et al. 2001) and Hemicentrotus pulcherrimus (ID: AB699316.1). In each genome, gene similarity searches (BLASTP and/or TBLASTN searches using the chimpanzee CMAH protein as query) were used to identify CMAH homologs. Where necessary, gene annotations were curated manually to resolve the intron/exon structure, and to determine signatures of inactivation/pseudogenization (missing exons, frameshift mutations, and premature stop codons).
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