Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination

Pruitt, Hawley C.; Devine, Daniel J.; Samant, Rajeev S.

While SOX10 is one potential mechanism by which NMI may travel to the nucleus, it is also possible that cytoplasmic transcription factors bind NMI and shuttle it into the nucleus to facilitate transcription. As mentioned previously, NMI expression has not been reported in fetal or adult brain tissue, and SOX10 is most notable for its role in the development of the neural crest, the peripheral nervous system and melanocytes. 61, 63 However, the amount of NMI protein in various adult and fetal tissues remains to be investigated. The interaction between SOX10 and NMI may have a broader functional impact, as emerging evidence shows that SOX10 is also expressed in myoepithelial cells in the breast, salivary and bronchial glands. 63 In addition, SOX10 expression was detected by immunohistochemistry in most molecular subtypes of breast cancer patient samples. 64